Hori Lab. Faculty of Science, Kyushu University

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Publications

Papers

  • Kanzaki, Y., Minami, R., Ota, K., Adachi, J., Hori, Y., Ohtani, R., Le Ouay, B., Ohba, M. Enhancing Performances of Enzyme/Metal-Organic Polyhedra Composites by Mixed-Protein Co-Immobilization.
    ACS Appl. Mater. Interfaces. 2024 doi: 10.1021/acsami.4c10146
  • Yoshida, R., Hori, Y., Uraguchi, D., Asano, K. BODNs as biocompatible brominating reagents: visible-light photocatalytic tyrosine modification under physiologically favorable conditions.
    Chem. Commun. 2024 doi: 10.1039/D4CC04171B
  • Kamikawa, T., Hashimoto, A., Yamazaki, N., Adachi, J., Matsushima, A., Kikuchi, K. Hori, Y. Bioisostere-conjugated fluorescent probes for live-cell protein imaging without non-specific organelle accumulation.
    Chem. Sci. 2024, 15, 8097 - 8105.
  • Torii, K., Benson, S., Hori, Y., Vendrell, M., Kikuchi, K. No-wash fluorogenic labeling of proteins for reversible photoswitching in live cells.
    Chem. Sci. 2024, 15, 1393 - 1401.
  • Torii, K., Hori, Y., Kikuchi, K. President Fluorescence Switching of a Probe Using a Photo-chromic Quencher with High Photostability Assisted by Protein-Surface Modification.
    Anal. Chem. 2023, 95, 8834-8841.
  • Nishiura, M., Hori, Y., Umeno, M., Kikuchi, K. Visualization of multiple localizations of GLUT4 by fluorescent probes of PYP-tag with designed unnatural warhead.
    Chem. Sci. 2023 , 14, 5925 - 5935. (Selected in 2023 most popular chemical biology articles collection of Chemical Science)
  • Reja, S. I. Hori, Y., Kamikawa, T., Yamasaki, K., Nishiura, M., Bull, S. D., Kikuchi, K. An "OFF-ON-OFF" fluorescence protein-labeling probe for real-time visualization of the degradation of short-lived proteins in cellular systems.
    Chem. Sci. 2022, 13, 1419-1427. (Selected in 2022 most popular analytical chemistry articles collection of Chemical Science)
  • Hori, Y., Nishiura, M., Tao, T., Baba, R., Bull, S. D., Kikuchi, K. Fluorogenic Probes for Detecting Deacylase and Demethylase Activity towards Post-Translationally-Modified Lysine Residues.
    Chem. Sci. 2021, 12, 2498–2503.
  • Torii, K., Hori, Y., Watabe, K., Kikuchi, K. Development of Photoswitchable Fluorescent Molecules Using Arylazopyrazole.
    Bull. Chem. Soc. Jpn. 2020, 93, 821–824.
  • Gao, J., Hori, Y., Shimomura, T., Bordy, M., Hasserodt, J., Kikuchi, K. Development of Fluorogenic Probes for Rapid High-Contrast Imaging of Transient Nuclear Localization of Sirtuin 3.
    ChemBioChem, 2020, 21, 656–662.
  • Kumar, N., Hori, Y., Nishiura, M., Kikuchi, K. Rapid No-Wash Labeling of PYP-Tag Proteins with Reactive Fluorogenic Ligands Affords Stable Fluorescent Protein Conjugates for Long-Term Cell Imaging Studies.
    Chem. Sci. 2020, 11, 3694–3701.
  • Gao, J., Hori, Y., Takeuchi, O., Kikuchi, K. Live-Cell Imaging of Protein Degradation Utilizing Designed Protein-Tag Mutant and Fluorescent Probe with Turn-Off Switch.
    Bioconjug. Chem. 2020, 31, 577–583.
  • Gao, J., Hori, Y., Nishiura, M., Bordy, M., Hasserodt, J., Kikuchi, K. Engineered Protein-Tag for Rapid Live-Cell Fluorogenic Visualization of Proteins by Anionic Probes.
    Chem. Lett. 2020, 49, 232–235.
  • Benson, S., Fernandez, A., Barth, N., de Moliner, F., Horrocks, M., Herrington, C. S., Abad, J. L., Delgado, A., Kelly, L., Chang, Z., Feng, Y., Nishiura, M., Hori, Y., Kikuchi, K., Vendrell, M. SCOTfluors: Small, Conjugatable, Orthogonal and Tunable Fluorophores for in vivo Imaging of Cell Metabolism.
    Angew. Chem. Int. Ed. 2019, 58, 6911–6915.
  • Hori, Y., Otomura, N., Nishida, A., Nishiura, M., Umeno, M., Suetake, I., Kikuchi, K. Synthetic-Molecule/Protein Hybrid Probe with Fluorogenic Switch for Live-Cell Imaging of DNA Methylation.
    J. Am. Chem. Soc. 2018, 140, 1686–1690.
  • Hori, Y., Hirayama, S., Kikuchi, K. Development of Cyanine Probes with Dinitrobenzene Quencher for Rapid Fluorogenic Protein Labelling.
    Philos. Trans. A Math. Phys. Eng. Sci. 2017, 375, pii. 20170018.
  • Mizukami, S., Kashibe, M., Matsumoto, K., Hori, Y., Kikuchi, K. Enzyme-Triggered Compound Release Using Functionalized Antimicrobial Peptide Derivatives.
    Chem. Sci. 2017, 8, 3047–3053.
  • Hirayama, S., Hori, Y., Benedek, Z., Suzuki, T., Kikuchi, K. Fluorogenic Probes Reveal a Role of GLUT4 N-Glycosylation in Intracellular Trafficking.
    Nat. Chem. Biol. 2016, 12, 853–859.
  • Wasin, T., Enomoto, K., Sakurai, T., Padalkar, V., Cheng, H., Tang, M., Horio, A., Sakamaki, D., Omichi, M., Saeki, A., Kikuchi, K., Hori, Y., Chiba, A., Saito, Y., Kamiya, T., Sugimoto M., Seki, S. Fabrication of ‘Clickable’ Polyfluorene Nanowires with High Aspect Ratio as Biological Sensing Platforms.
    ACS Sensors 2016, 1, 766–774.
  • Kamikawa, Y., Hori, Y., Yamashita, K., Jin, L., Hirayama, S., Standley, D. M., Kikuchi, K. Design of a Protein Tag and Fluorogenic Probe with Modular Structure for Live-Cell Imaging of Intracellular Proteins.
    Chem. Sci. 2016, 7, 308–314.
  • Hori, Y., Hirayama, S., Sato, M., Kikuchi, K. Redesign of a Fluorogenic Labeling System to Improve Surface Charge, Brightness, and Binding Kinetics for Imaging the Functional Localization of Bromodomains.
    Angew. Chem. Int. Ed. 2015, 54, 14368–14371.
  • Baba, R., Hori, Y., Kikuchi, K. Intramolecular Long-Distance Nucleophilic Reactions as a Rapid Fluorogenic Switch Applicable to the Detection of Enzymatic Activity.
    Chem. Eur. J. 2015, 21, 4695–4702.
  • Hori, Y., Norinobu, T., Sato, M., Arita, K., Shirakawa, M., Kikuchi, K. Development of Fluorogenic Probes for Quick No-Wash Live-Cell Imaging of Intracellular Proteins.
    J. Am. Chem. Soc. 2013, 135, 12360–12365. (Reviewed in JACS Spotlight)
  • Hori, Y., Nakaki, K., Sato, M., Mizukami, S., Kikuchi, K. Development of Protein-Labeling Probes with Redesigned Fluorogenic Switch Based on Intramolecular Association for No-Wash Live-Cell Imaging.
    Angew. Chem. Int. Ed. 2012, 51, 5611–5614.
  • Baba, R., Hori, Y., Mizukami, S. Kikuchi, K. Development of Fluorogenic Probe with Transesterification Switch for Detection of Histone Deacetylase Activity.
    J. Am. Chem. Soc. 2012, 134, 14310–14313. (Reviewed in JACS Spotlight)
  • Dhara, K., Hori, Y., Baba, R., Kikuchi, K. Fluorescent Probe for Detection of Histone Deacetylase Activity Based on Aggregation-Induced Emission.
    Chem. Commun. 2012, 48, 11534–11536.
  • Watanabe, S., Mizukami, S., Akimoto, Y., Hori, Y., Kikuchi, K.         Intracellular Protein Labeling with Prodrug-like Probes Using a Mutant b-Lactamase Tag.
    Chem. Eur. J. 2011, 17, 8342–8349.
  • Yoshimura, A., Mizukami, S., Hori, Y., Watanabe, S., Kikuchi, K. Cell-Surface Protein Labeling with Luminescent Nanoparticles through Biotinylation by Using Mutant b-Lactamase-Tag Technology.
    Chembiochem2011, 12, 1031–1034.
  • Watanabe S, Mizukami S, Hori Y, Kikuchi K., Multicolor Protein Labeling in Living Cells Using Mutant b-Lactamase-Tag Technology.
    Bioconjug. Chem. 2010, 21, 2320–2326.
  • Mizukami, S., Hosoda, M., Satake, T., Okada, S., Hori, Y., Furuta, T., Kikuchi, K. Photocontrolled Compound Release System Using Caged Antimicrobial Peptide.
    J. Am. Chem. Soc.2010, 132, 9524–9525.
  • Hori, Y., Egashira, Y., Kamiura, R., Kikuchi, K. Noncovalent-Interaction -Promoted Ligation for Protein Labeling.
    Chembiochem 2010, 11, 646–648.
  • Hori, Y., Ueno, H., Mizukami, S., Kikuchi, K. Photoactive Yellow Protein-Based Protein Labeling System with Turn-on Fluorescence Intensity.
    J. Am. Chem. Soc.2009, 131, 16610–16611.
  • Mizukami, S., Watanabe, S., Hori, Y., Kikuchi, K. Covalent Protein Labeling Based on Noncatalytic b-Lactamase and a Designed FRET Substrate.
    J. Am. Chem. Soc. 2009, 131, 5016–5017.
  • Vila-Perelló, M., Hori, Y., Ribó, M., Muir, T. W. Activation of Protein Splicing by Protease- or Light-Triggered O to N Acyl Migration.
    Angew. Chem. Int. Ed. 2008, 47, 7764–7767.
  • Mizukami, S., Takikawa, R., Sugihara, F., Hori, Y., Tochio, H., Wälchli, M., Shirakawa, M., Kikuchi, K. Paramagnetic Relaxation-Based 19F MRI Probe to Detect Protease Activity.
    J. Am. Chem. Soc. 2008, 130, 794–795.
  • Hori Y., Sugiura Y. Effects of Zn(II) Binding and Apoprotein Structural Stability on the Conformation Change of Designed Antennafinger Proteins.
    Biochemistry 2004, 43, 3068–3074.
  • Hori Y., Sugiura Y. Conversion of Antennapedia Homeodomain to Zinc Finger-like Domain: Zn(II)-Induced Change in Protein Conformation and DNA Binding.
    J. Am. Chem. Soc. 2002, 124, 9362–9363.
  • Nagaoka, M., Kaji, T., Imanishi, M., Hori, Y., Nomura, W., Sugiura, Y. Multi-Connection of Identical Zinc Finger: Implication for DNA Binding Affinity and Unit Modulation of Three Zinc Finger Domain.
    Biochemistry 2001, 40, 2932–2941.
  • Hori Y., Suzuki K., Okuno Y., Nagaoka M., Futaki S., Sugiura Y. Artificial Zinc Finger Peptide Containing a Novel His4 Domain.
    J. Am. Chem. Soc. 2000, 122, 7648–7653.
  • Imanishi, M., Hori, Y., Nagaoka, M., Sugiura, Y. DNA-Bending Finger: Artificial Design of 6-Zinc Finger Peptides with Polyglycine Linker and Induction of DNA Bending.
    Biochemistry 2000, 39, 4383–4390.

Books・Reviews

  • 足立惇弥, 寺井琢也, 針尾紗彩, Robert E. Campbell, 堀　雄一郎 「生体を観察するための化学 蛍光タンパク質とタグタンパク質」
    現代化学, 2024, 7月, 640, 33-39.
  • 上川　拓也, 堀　雄一郎 「タンパク質標識技術によるイメージング法の進展」
    高分子, 2023, 72, 379-381.
  • Reja, S. I., Minoshima, M., Hori, Y., Kikuchi, K. Near-Infrared Fluorescent Probes: a Next-Generation Tool for Protein-Labeling Applications.
    Chem. Sci., 2021, 12, 3437–3447.
  • 堀 雄一郎「タンパク質ラベル化技術を用いたメチル化DNAの蛍光イメージング」
    顕微鏡, 2020, 55, 90–93
  • 堀 雄一郎, 菊地 和也 「タンパク質ラベル化技術を応用したメチル化DNAの可視化」
    生産と技術, 2020, 72, 31–36
  • 堀 雄一郎, 菊地 和也 「生体制御分子を可視化するバイオプローブ」CSJ Current Review. 2020, 36, 24–29
  • Hori, Y., Kikuchi, K. Chemical Tools with Fluorescence Switches for Verifying Epigenetic Modifications.
    Acc. Chem. Res. 2019, 52, 2849–2857.
  • Kumar, N., Hori, Y., Kikuchi, K. Photoactive Yellow Protein and its Chemical Probes: an Approach to Protein Labeling in Living Cells.
    J. Biochem. 2019, 166, 121–127
  • Reja, S. I., Minoshima, M., Hori, Y., Kikuchi, K. Development of an Effective Protein-Labeling System Based on Smart Fluorogenic Probes.
    J. Biol. Inorg. Chem. 2019, 24, 443–455.
  • Kumar, N., Hori, Y., Kikuchi, K. Live-Cell Imaging of DNA Methylation Based on Synthetic-Molecule/Protein Hybrid Probe.
    Chem. Rec. 2018, 18, 1672–1680.
  • 堀 雄一郎, 菊地 和也 「生細胞でのタンパク質蛍光標識技術の開発と糖鎖機能の解明」
    生体の科学, 2017, 68, 2–3.
  • 堀 雄一郎, 菊地 和也 「GLUT4 の細胞内動態を可視化する 化学アプローチで明らかとなった糖鎖の役割」
    化学と生物, 2017, 55, 659–660.
  • 堀 雄一郎, 菊地 和也 「ケミカルバイオロジーと分子イメージング」
    感染・炎症・免疫, 2017, 47, 48–57.
  • 堀　雄一郎、菊地　和也 「ヒストンデアセチラーゼ活性を検出する発蛍光プローブの開発」
    薬学雑誌, 2015, 135, 23–29.
  • 堀　雄一郎、菊地　和也 「ヒストン脱アセチル化酵素の活性を検出する化学プローブの開発」
    生体の科学, 2014, 65, 559–564.
  • Mizukami, S., Hori, Y., Kikuchi, K. Small-Molecule-Based Protein-Labeling Technology in Live Cell Studies: Probe-Design Concepts and Applications.
    Acc. Chem. Res. 2014, 47, 247–256.
  • 堀 雄一郎,　菊地和也 「PYPタグと発蛍光プローブを利用した生細胞タンパク質イメージング技術の開発」
    Dojin News, 2014, 150,1–6.
  • 堀 雄一郎,　菊地和也 「PYPタグと発蛍光プローブを用いた生細胞タンパク質イメージング法の開発と応用」
    バイオサイエンスとバイオインダストリー, 2014, 72, 230–231.
  • 堀 雄一郎,　菊地和也 「タンパク質イメージング技術の新展開」
    バイオサイエンスとバイオインダストリー, 2014, 72, 188–189.
  • 堀　雄一郎「若手研究者からのメッセージ」
    日本化学会バイオテクノロジー部会ニュースレター, 2014, 18(1), 14–16.
  • Hori, Y., Kikuchi, K. Protein Labeling with Fluorogenic Probes for No-Wash Live-Cell Imaging of Proteins.
    Curr. Opin. Chem. Biol. 2013, 17, 644–650.
  • 堀　雄一郎、菊地　和也 「PYPタグと発蛍光プローブを利用した蛋白質の生細胞蛍光イメージング」
    化学と生物, 2013, 51, 189–192.
  • 堀　雄一郎、菊地　和也 「発蛍光型スイッチ機能を有した蛋白質ラベル化技術の開発による細胞内標的分子イメージング」
    CSJ Current Review, 2013, 12, 162–168.
  • 堀　雄一郎、菊地　和也 「PYPタグと発蛍光プローブを用いた細胞内タンパク質ラベル化技術の開発と応用」
    日本化学会生体機能関連化学部会ニュースレター, 2013, 28, 10–13.
  • 堀　雄一郎、菊地　和也 「発蛍光プローブによる次世代型タンパク質標識技術　－化学アプローチに基づくタンパク質蛍光イメージングの新展開」
    化学, 2012, 67, 68–69.
  • Sadhu, K. K., Mizukami, S., Hori, Y., Kikuchi, K. Switching Modulation for Protein Labeling with Activatable Fluorescent Probes.
    Chembiochem 2011, 12, 1299–1308.
  • 堀　雄一郎，菊地　和也 「発蛍光プローブによるタンパク質の無洗浄生細胞蛍光イメージング」
    日本化学会生体機能関連化学部会ニュースレター, 2012, 27, 2–5.
  • 堀　雄一郎，菊地　和也　「合成蛍光プローブと発現タンパク質を用いた新規タンパク質ラベル化システム」
    生化学，2011, 83, 135–139.
  • 堀 雄一郎「蛍光蛋白質の夜明け：GFPの構造解明」
    蛋白質 核酸 酵素「ケミカルバイオロジー」2007, 52, 1768–1769.
  • Imanishi, M., Hori, Y., Nagaoka, M., Sugiura, Y. Design of Novel Zinc Finger Proteins: Toward Artificial Control of Specific Gene Expression.
    Eur. J. Pharm. Sci. 2001, 13, 91–97.

Others

Patent

  • 発明の名称：「メチル化DNAを蛍光標識する方法」, 出願人：大阪大学, 発明者：菊地 和也, 堀 雄一郎, 乙村　法道, 登録番号：特許第6274632号, 登録日：2018年1月19日, 出願月日：2015年2月18日
  • 発明の名称：「蛋白質を蛍光標識する方法」, 出願人：大阪大学, 発明者：菊地 和也，堀 雄一郎, 上野 秀樹, 出願番号：PCT/JP2010/054024, 出願月日：2010年3月10日
  • 発明の名称：「タンパク質を二段階標識する方法」, 出願人：大阪大学, 発明者：菊地 和也, 堀 雄一郎, 上野 秀樹, 出願番号：特願2009-056306, 出願月日：2009年3月10日
  • 発明の名称：「蛋白質を蛍光標識する方法」, 出願人：大阪大学, 発明者：菊地 和也, 堀 雄一郎, 上野 秀樹, 登録番号：特許第5299932号, 登録日：2013年6月28日, 出願月日：2009年3月10日
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