Publications

2022

Hosose, M., Shirane, K., Ishibashi, T., Ito, K., Tagawa, K., and Matsushima, A.: Neuropeptide gene expression in the fetal mouse brain　exposed to an endocrine-disrupting chemical, Peptide Science 2021, 99-100 (2022).

2021

Tagawa, K., Suyama, K., Kesamaru, H., Masuya, T., Nose, T., Matsushima, A. Design and synthesis of a universal coactivator peptide binding to the estrogen receptor and Nurr1. Peptide Science 2020, 123-124 (2021).

2019

Masuya, T., Tada, Y., Lui, A., and Matsushima, A.: Evaluation of the binding ability of an orphan nuclear receptor nurr1 to synthetic peptides. Peptide Science 2018, 113 (2019).

2018

Sugiyama, M., Fujita, T., Liu, X., Yutaka, M., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.: Phe 271³⁹ of Thronbin Receptor PAR-1 is a specific target of Phe-2-phenl group of its tethered ligand. Peptide Science 2017, 94-95 (2018).

Liu, X., Nakagawa, H., Sugiyama, M., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.: Homodimer function of human nuclear receptor ERRa evidenced using a-helix peptides in the dimer interface. Peptide Science 2017, 190-191 (2018).

Liu, X., Shimohigashi, M., Sugiyama, M., Matsushima, A., and Shimohigashi, Y.: Mutual co-work between nuclear receptor ERa and ERRg requires their homodimerization. Peptide Science 2017, 198-199 (2018).

2017

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X., and Shimohigashi. Y.: Docking simulation to elucidate the labeled cysteine residue of the nociception receptor ORL1 using a Cys(Npys)-containing peptide ligand. Peptide Science 2016, 87-88 (2017).

2016

Matsushima, A., Nishiimura, H., Liu, X., Takesue, Y., Matsuyama, Y., and Shimohigashi. Y.: Comprehensive structural analysis of the nociceptin ORL1 receptor by means of virtual and experimental Ala-scanning combinated methods. Peptide Science 2015, 149-150 (2016).

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A., and Shimohigashi. Y.: Functional role of the Phe-Phe stacking microswitch in the ORL1 nociceptin receptor activation. Peptide Science 2015, 147-148 (2016).

Tokumaru, A., Matsuo, A., Umeno, S., Matsuyama, Y., Nakamura, M., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.: Expression analysis of neuropeptide PDF mRNA in the hypoactive and hyperactive fruit flies Drosophila melanogaster. Peptide Science 2015, 317-318 (2016).

Matsuyama, Y., Nishimura H., Liu, X., Matsushima, A., and Shimohigashi. Y.: Comparative analysis of the ligand binding domain secondary structures of human nuclear receptors. Peptide Science 2015, 337-338 (2016).

Sugiyama, M., Motomatsu, Y., Matsuyama, Y., Kajiyama, S., Kameda, T., Saito, T., Uchimura, E., Liu, X., Matsushima, A., and Shimohigashi. Y.: SCN Circadian rhythm signal transduction neuropeptides evoke hypoactive phenotype differently in male and female mice. Peptide Science 2015, 53-54 (2016).

Motomatsu, Y., Nishimura, H., Matsusyama, Y., Liu, X., Matsushima, A., and Shimohigashi. Y.: ORL1 Nociceptin receptor response of opioid peptides derived from proenkephalin precursor protein. Peptide Science 2015, 181-182 (2016).

Sakito, S., Liu, X., Fujiyama, A., Matsushima, A., and Shimohigashi. Y.: Do the estrogen receptors function as a homodimer? experimental validation of homodimerization by inhibitory peptides. Peptide Science 2015, 335-336 (2016).

2015

Liu, X., Matsushima, A., and Shimohigashi. Y.: A novel method identify and quantify the coactivator proteins that couple with human nuclear receptor: the use of interacting interface a-helix peptide for quantitative inhibition. Peptide Science 2014, 347-348 (2015).

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A., and Shimohigashi. Y.: GPCR functional role of Phe-269 and Phe-221 in the molecular switching of ORL1 nociceptin receptor activation. Peptide Science 2014, 203-204 (2015).

Umeno, S., Matsuo, A., Matsuyama, Y., Nakamura, M., Koga, K., Liu, X., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.: Bisphenol A-induced substantial peak decay of Drosophila circadian neuropeptide hugin mRNA expression. Peptide Science 2014, 41-42 (2015).

Matsuyama, Y., Nishimura H., Liu, X., Matsushima, A., and Shimohigashi. Y.: Structural and molecular evolutionary analysis of the ligand-binding domain of forty-eight human nuclear receptors. Peptide Science 2014, 347-348 (2015).

Sugiyama, M., Kajiyama, S., Saito, T., Uchimura, E., Motomatsu, Y., Matsuo, A., Matsushima, A., and Shimohigashi. Y.: Alternative polyadenylation analyses of neuropeptide genes in bisphenol A-exposed hypoactive mouse brain. Peptide Science 2014, 345-346 (2015).

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Kuramitsu, Y., Inamine, S., Matsushima, A., and Shimohigashi. Y.: Receptor selectivity and specificity of a series of opioid peptides latent in the proenkephalin precursor protein. Peptide Science 2014, 205-206 (2015).

Nishimura, H., Li, J., Isozaki, K., Takesue, Y., Liu, X., Shimohigashi, M., Inamine, S., Matsushima, A., and Shimohigashi. Y.: The molecular switching of ORL1 nociceptin receptor in activation/inactivation. Peptide Science 2014, 201-202 (2015).

Matsushima, A., Koyanagi, O.K., Nishimura, H., Inamine, S., Motomatsu, Y., and Shimohigashi. Y.: An in silico genomic search of endomorphin-like opioid peptides. Peptide Science 2014, 281-282 (2015).

2014

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Costa, T., and Shimohigashi, Y.: Functionally Essential Amino Acid Residues in ORL1 Nociceptin Receptor for Ligand-stimulated Receptor Activation. Peptide Science 2013, 333-334 (2014).

Matsuo, A., Umeno, S., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.: Bisphenol A-induced Epigenetic Mutations in Circadian Pacemaker Neuropeptide mRNAs of Hyperactive Drosophila Fruit Flies. Peptide Science 2013, 457-458 (2014).

Matsushima, A., Nishimura, H., Inamine, S., and Shimohigashi, Y.: Multiple and Simultaneous Cys→Ala Mutations of ORL1 Nociceptin Receptor to Identify the Affinity Binding site of Cys(Npys)-Elongated RYYRIK Peptide Antagonist. Peptide Science 2013, 413-414 (2014).

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., and Shimohigashi, Y.: Constitutive α-Helix-peptides Required for Functional Dimerization of Estrogen-related Receptor γ (ERRγ). Peptide Science 2013, 429-430 (2014).

Sugiyama, M., Matsuo, A., Saito, T., Uchimura, E., Liu, X., Matsushima, A., and Shimohigashi, Y.: Expression and Mutation Analyses of Brain Neuropeptide Genes of Rndocrine-disrupting Bisphenol A-exposed Hypoactive Mouse. Peptide Science 2013, 453-454 (2014).

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T., and Shimohigashi, Y.: Structure-activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs. Peptide Science 2013, 319-320 (2014).

Umeno, S., Matsuo, A., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.: Influence Analysis of the Circadian Evening Pacemaker Neuropeptide hugg Gene in the Bisphenol A-exposed Fruit Fly Drosophila Brain. Peptide Science 2013, 455-456 (2014).

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Inamine, S., Kuramitsu, Y., Matsushima, A., and Shimohigashi, Y.: Specific Role of Phe Residues in Opioid Peptide Met-enkephalin- Arg-Phe in Binding to All Three Opioid Receptors. Peptide Science 2013, 317-318 (2014).

Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A., and Shimohigashi, Y.: Three-dimensional Docking Modeling to Human Nuclear Receptors for Exploration of Bisphenol-A Targeting Receptors. Peptide Science 2013,459-460 (2014).

2013

Nishio, K., Nishimura, H., Suyama, K., Matsushima, A., Nose, T., and Shimohigashi, Y.: Halogenated Phe-containing endomorphin-2 analogs with mixed agonist and antagonist activities. Peptide Science 2012, 25-26 (2013).

Matsuo, A., Nakamura, M., Takeda, Y., Matsuyama, Y., Sumiyoshi, M., Liu, X., Matsushima, A. Shimohigashi, M., and Shimohigashi, Y.: The impact of bisphenol A-feeding on the Drosophila neuropeptide PDF mRNA structure. Science 2012, 75-76 (2013).

Nishimura, H., Inamine, S., Li, J. Matsushima, A., and Shimohigashi, Y.: Exploration of pharmacological chaperone for rescue of misfolded and/or unfolded ORL1 nociceptin receptor proteins. Peptide Science 2012, 115-118 (2013).

Matsushima, A., Nishimura, H., Inamine, S., and Shimohigashi, Y.: Identification of affinity binding site of Cys(Npys)-elongated RYYRIK peptide antagonist by means of Cys®Ala mutated ORL1 nociceptin receptors. Peptide Science 2012, 207-208 (2013).

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T., and Shimohigashi, Y.: High-precision binding assay procedure of tachykinin receptor NK-1 for highly potent Substance P analogs. Peptide Science 2012, 213-214 (2013).

Inamine, S., Nishimura, H., Li, J., Matsushima, A. Costa, T., and Shimohigashi, Y.: Two different binding modes of peptide library-based antagonist acyl-RYYRIK amide in the orl1 nociceptin receptor. Peptide Science 2012, 229-230 (2013).

Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A., Nose, T., and  Shimohigashi, Y. : Bisphenol-binding pocket of constitutively active nuclear receptor CAR: Docking modeling for close-packing. Peptide Science 2012, 401-402 (2013).

2012

Inamine, S., Nishimura, H., Li, J., Matsushima, A., Nose, T., Costa, T., and Shimohigashi Y.: Receptor Binding Characteristics of Tritium-labeled Pure antagonist Peptide for Hyperalgesic nociceptin ORL1 receptor. Peptide Science 2011, 183-184 (2012).

Matsushima, A., Nishimura, H., Inamine, S., Uemura, S., and Shimohigashi Y.: Affinity labeling of the ORL1 nociceptin receptor by Cys(Npys)-elongated RYYRIK peptide antagonist. Peptide Science 2011, 179-180 (2012).

Nishio, K., Hishimura, H., Suyama, K., Abe, Y., Matsushima, A., Nose, T., and Shimohigashi Y.: Effects ofthe halogenation of Phe-phenyl group of two consecutive residues in endomorphin-2 on the interaction with the m–opioid receptors. Peptide Science 2011, 171-172 (2012).

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Nose, T.,  Costa, T., and Shimohigashi Y.: Structural essentials of hyperalgesic nococeptin ORL1 receptor for ligand binding and receptor activation. Peptide Science 2011, 33-34 (2012).

2011

Sato, K., Horiuchi, Y., Matsushima, A., and Shimohigashi, Y.: QCM-analyses of the intermolecular interaction between prion protein N-terminal domains having increased number of octapeptide repeat. Peptide Science 2010, 128 (2011).

Inamine, S., Li, J., Nishimura, , Matsushima, A., Nose, T., Costa, T. and Shimohigashi, Y.: Exploration of the binding site of ORL1 nociceptin receptor antagonist. Peptide Science 2010, 167 (2011).

Nishimura, H., Li, J., Inokuchi, N., Koikawa, S., Matsushima, A., Nose, T., Costa, T. and Shimohigashi, Y.: The Trp residue of opioid receptor TM5 present at the cell membrane interface is a molecular anchor for full activation. Peptide Science 2010 , 175 (2011).

2010

Liu, X., Matsushima, A., Okada, H., and Shimohigashi, Y.: Functional role of the C-terminal Helix 12 peptide in the receptor activation mechanism of estrogen-related receptor g (ERRg). Peptide Science 2009, 435–436 (2010).

Sato, K., Horiuchi, Y., Matsushima, A., and shimohigashi, Y.: The preparation and purification of prion protein N-terminal domain with fluctuations in the number of octapeptide repeat. Peptide Science 2009, 433–434 (2010).

Li, J., Isozaki, K., Matsushima, A., Nose, T., Costa, T., and Shimoohigashi, Y.: Structure-function analysis of nociceptin receptor ORL1 by the site-directed mutagenesis. Peptide Science 2009, 219–220 (2010).

Shimohigashi, M., Itoh, T.Q., Honda, T., Saito, M., Koga, K., Takahashi, K., Matsushima, A., Ueda, R., Tanimura T., Shimohigashi, Y., and Matsumoto A.: The role of the peptide PAP coded in pdf Peptide Science 2009, 217–218 (2010).

Horiuchi, Y., Matsushima, A., and Shimohigashi, Y.: The direct measure of intermolecular interaction of prion protein N-terminal octapeptide repeats by the quarts crystal microbalance (QCM). Peptide Science 2009, 207–208 (2010).

Kawanaka, C., Matsushima, A., Takeda, Shimohigashi, Y., M., and Shimohigashi, Y.: Identification of circadian neuropeptide PDF mRNA isoforms in the housefly Musca domestica. Peptide Science 2009, 145–146 (2010).

Nishimura, H., Li, J., Inokuchi, N., Koikawa, A., Matsuhima, A., Nose, T., Costa, T., and Shimohigashi, Y.: The functional role of Trp present at the cell membrane interface in the opioid receptor activation. Peptide Science 2009, 23–24 (2010).

2009

Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, Y. and Shimohigashi, M.: Bisphenol A-specific nuclear receptor ERRg: structure-function analysis of the two novel isoforms lacking vital peptide fragment in the ligand binding domain. Peptide Science 2008, 517-518 (2009).

Ikeda, S., Matsushim, A., and Shimohigashi, Y.: ERa/ERRa nuclear receptor heterodimer directly linked by a flag peptide. Peptide Science 2008, 511-512 (2009).

Horiuchi, Y., Hattori, E., Yokotani, S., Matsushima, A., and Shimohigashi, Y.: Molecular recognition of prion protein via its N-terminal octapeptide repeat Structure. Peptide Science 2008, 513-516 (2009).

Matsushima, A., Okada, H., Liu, X., Tokunaga, T., Teramoto, T., Kakuta, Y., Shimohigashi, Y.: Induced-fit type ligand binding guided by free-rotatory Leu residue present in the 7th a-helix peptide in the estrogen-related receptor g (ERRg). Peptide Science 2008, 521-522 (2009).

2008

Hattori, E., Yokotani, S., Horiuchi, Y., Matsushima, A., and Shimohigashi, Y.: The effect of amino acid substitution on oligomerization of octapeptide repeat structure in prion protein. Peptide Science 2007, 239-242 (2008).

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M., and Shimohigashi, Y.: Structural requirement of housefly FMRFamide peptides in its receptor activation. Peptide Science 2007,313-314 (2008).

Takeda, Y., Koga, K., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.: The output mechanism of circadian pacemaker neuropeptide PDF in the regulation of bimodal locomotor distribution. Peptide Science 2007, 65-68 (2008).

Li, J. Isozaki, K., Matsushima, A., Nose, T., Costa, T., and Shimohigashi, Y.: Optimization of the N-terminal group of Ac-RYYRIK-NH₂ as ORL1 receptor antagonist. Peptide Science 2007, 257-260 (2008).

2007

Tokunaga, T., Liu, X., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M., and Shimohigashi, Y.: Conformation change of a-helix peptide for sensing of deactivation of nuclear peceptor: Immunoassay using polyclonal antibody specific for the C-terminal a-helix 12 of estrogen-related receptor g (ERRg). Peptide Science 2006, 176, (2007).

Kaneki, A., Yoshida, T., Isozaki, K., Matsushima A., Shimohigashi, M., and Shimohigashi, Y.: Molecular cloning and in situ hybridization of circadian neuropeptide PDF receptor in the fruit fly Drosophila melanogaster. Peptide Science 2006, 263, (2007).

Koga, K., Yakayama, Y., Hiramura, D., Takeda, Y., kaneki, A., Matsushima, A., Shimohigashi, Y., and Shimoshigashi, M.: Immunological confirmation of circadian-related neuropeptide PDF-isoform peptide in the cricket Gryllus bimaculatus. Peptide Science 2006, 262, (2007).

Takeda, Y., Sumiyuki, M., Koga, K., Ito, M., Matsushima, A., Shimohigashi, Y., and Shimohigashi, M.: Multiple post-transcriptional regulations in circadian pacemaker neuropeptide pdf gene. Peptide Science 2006, 260, (2007).

Matsushima, A. Koretsune, Y., Kaneki, A. Isozaki, K., Shimohigashi, M., and Shimohigashi, Y.: Structure-activity studies of FMRFamide-related peptides in activating the specific receptor present in the housefly Musca domestica. Peptide Science 2006, 174, (2007).

2006

Honda, T., Matsushima, A., Hiramura, D., Sumida, K., Takeda, Y., Sato, S., Meinertzhagen I.A., Shimohigashi, Y., and Shimohigashi, M.: Immunological evidences of circadian neuropeptide PDF isoform present at the lamina outer cells and varicose network in the optic lobes of the cricket Gryllus bimaculatus. Peptide Science 2005, 181-184 (2006).

Koga, K., Sato S., Horiuchi Y., Matsushima, A., and Shimohigashi, Y.: Design and synthesis of a-helix peptide binding to prion protein N-terminal octarepeat domain. Peptide Science 2005, 209-210 (2006)

Okada, H., Tokunaga, T., Shirasu N., Matsushima, A., Nose, T., and Shimohigashi Y.: a-helix peptides for bio-panning in the phage display method to obtain the antibodies specific for conformation-change nuclear receptors. Peptide Science 2005, 291-294 (2006).

Yokotani, S., Honda, T., Kawano, M., Matsuhima A., and Shimohigashi, Y.: Monoclonal antibody sensing assay for conformation change induced by metal binding to prion protein N-terminal octarepear domain. Peptide Science 2005, 455-456 (2006).,

Sato, S., Jonathan C., Corrins, Takeda, Y., Kaneki, A., Matsushima, A., Shimohigashi, Y., and Shimohigashi, M.: Identification of novel isoforms of the circadian neuropeptide PDF in the silk moth Bombyx mori and their expression in brain. Peptide Science 2005, 99-100 (2006).

Matsushima, A., Horiuchi, Y., Yokotani, S., Kawano, M., and Shimohigashi, Y.: Specific dimerization of prion protein N-terminal domain. Peptide Science 2005, 457-458 (2006).

2005

Shimohigasi M., Honda T., Matsushima A., Sumida K., Meinertzhagen, I.A., Shimohigasi Y., and Tominaga Y.: Immunocytochemical studies on the circadian neuropeptide PDF in the Cricket Gryllus bimaculatus. Peptide Science 2004, 339-342 (2005).

Sumida, K., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y., and Shimohigashi, M.: Immunocytochemical identification of mature peptide formation for the circadian neuromodulator PDF in the housefly Musca domestica. Peptide Science 2004, 347-350 (2005).

Kawano, M., Honda, T., Horiuchi, Y., Yokotani, S., Matsushima, A., Nose, T., and Shimohigashi, Y.: Conformation change-senseing assay using monoclonal antibody for N-terminal octapeptide repreat region of prion protein. Peptide Science 2004, 355-356 (2005).

Takeda, Y., Shirasu, N., Sato, S., Matsushima, A., Chuman, Y., Tominaga, Y., Shimohigashi, M., and Shimohigashi, M.: Triplicate alternative splicings that produce multiple variants of the PERIOD protein in the silk moth Bombyx mori by deletion/Insertion of peptides. Peptide Science 2004, 203-206 (2005).

Liu, X., Matsushima, A., Shirasu, N., Tominaga, Y., Shimohigashi, M., Shimohigashi, Y., and Nose, T.: Structural characteristics of Drosophila estrogen-related receptor ligand binding domain to capture the peptide and non-peptide ligands. Peptide Science 2004, 303-304 (2005).

Sato, S., Sumida, K., Hiramura, D., Matsushima, A., Tominaga, Y., Shimohigashi, Y., and Shimohigashi, M. : cDNA cloning and mRNA expression of the circadian neuropeptide PDF in the silk moth Bombyx mori. Peptide Science 2004, 197-200 (2005).

Yokotani, S., Matsushima, A., Nose, T., Morishita, F., and Shimohigashi Y.: Bioactive conformation of a D-Trp-containing cardioexcitatory tripeptide isolated from the sea hare Peptide Science 2004, 539-540 (2005).

Horiuchi, Y., Kawano, M., Yokotani, S., Honda, T., Matsushima, A., Nose, T., and Shimohigashi, Y.: Structural characteristics of the N-Terminal octapeptide repeat region of Prion protein in self-polymerization. Peptide Science 2004, 317-318 (2005).

Matsushima A., Yokotani, S., Koretsune, Y., Meinertzhagen, I.A., Tominaga, Y., Shimohigashi, M., and Shimohigashi, Y.: FMRFamide-related peptides in the nervous system of the housefly Musca domestica: cDNA cloning and actions on clam heart contraction. Peptide Science 2004, 157-160 (2005).

2004

Kawano, M., Horiuchi, Y., Honda, T., Yokotani, S., Matushima, A, Nose, T., and Shimohigashi, Y.: Structural requirements of the N-terminal octapeptide repeat of prion protein. Peptide Science 2003,375-378 (2004).

Kaneki, A., Matsushima, A., Takeda, Y., Yokotani, S., Ozaki, M., Shimohigashi, M., and Shimohigashi, Y.: Primary structure analysis of circadian neuropeptide PDF and precursors in insect cicadae and flies. Peptide Science 2003, 483-486 (2004).

Yokotani, S., Matsushima, A., Nose, T., Shimohigashi, Y., and Morishita, F.: Effect of the Phe-Phenyl H-F subsutitution in the sea hare Aplysia neuropeptide H-Asn-d-Phe-NH2 on the conformation and contraction activity. Peptide Science 2003, 459-462 (2004).

Takeda, Y., Shirasu, N., Sato, S., Matsushima, A., Chuman, Y., Shimohigashi, M., and Shimohigashi, Y.: Two distinctly different isoforms with/without pentapeptide fragment in the silk moth clock protein peptide. Peptide Science 2003, 473-476 (2004).

Honda, T., Chuman, Y., Matsushima, A., Nose, T., Sakaguchi, K., Onoue, H., Tominaga, Y., Shimohigashi, Y., and Shimohigashi, M.: Localization profiles of circadian neuropeptide PDF in brain of the cricket Gryllus bimaculatus. Peptide Science 2003, 81-84 (2004).

Matsushima, A., Yokotani, S., Shimohigashi, Y., Tominaga, Y., Shimohibashi, M.: cDNA cloning and in situ hybridization studies of sulfated peptide, sulfakinin, on housefly Musca domestica. Peptide Science 2003, 459-462 (2004).

2003

Sato, S., Oka, H., Matsushima, A., Tominaga, Y., Shimohigashi, Y., and Shimohigashi, M.: Structural analysis of PERIOD-PAS domain binding regions in insect clock protein TIMELESS. Peptide Science 2002, 429-432 (2003).

Tokunaga, T., Ohtani, M., Matsushima, A., Nose, T., Shimohigashi, Y., Aimoto, S., and Shimohigashi, Y.: The Structure-activity studies of Drosophila FMRFamide-related peptides. Peptide Science 2002, 265-268 (2003).

Honda, T., Chuman, Y., Matsushima, A., Asai, D., Nose, T., Sakaguchi, K., Onoue, H., Tominaga, Y., Shimohigashi, Y., and Shimohigashi, Y.: Localization profiles of the precursor protein of circadian rhythm pacemaker hormone PDF in Gryllus Peptide Science 2002, 433-436 (2003).

Matsushima, A., Nose, T., Tomioka, K., Shimohigashi, M., and Shimohigashi, Y.: Structural characterization of the house fly PDF, a circadian rhythm pacemaker hormone. Peptide Science 2002, 333-336 (2003).

2002

Asai, D., Tokunaga, T., Matsushima, A., Sato, S., Chuman, Y., Nose, T., Tominaga, Y., Shimohigashi, Y., and Shiimohigashi, M.: Design and preparation of universal anti-PERIOD antibodies and their immunoresponses. Peptide Science 2001, 399-402 (2002).

Tokunaga, T., Ohtani, M., Matsushima, A., Chuman, Y., Nose, T., Shimohigashi, Y., Aimoto, S., and Shimohigashi, Y.: Contractile activity of Drosophila FMRFamide-related peptides in the Meretrix Lusoria heart muscle. Peptide Science 2001, 167-170 (2002).

Sato, S., Matsushima, A., Chuman, Y., Tominaga, K., Shimohigashi, Y., and Shimohigashi, M.: cDNA cloning of PDF peptide precursors in housefly and last summer cicada. Peptide Science 2001, 139-142 (2002).

Matsushima, A., Chuman, Y., Sato, S., Tominaga, Y., Shimohigashi, Y., and Shimohigashi M.: Structure and function of nuclear localization signal peptide present in circadian rhythm hormone peptide precursor. Peptide Science 2001, 159-162 (2002).

Chuman, Y., Matsushima, A., Shimohigashi, Y., and Shimohigashi M.: Circadian rhythm pacemaker neuropeptide ‘PDF’ in nocturnal insect cricket gryllus bimaculatus: cDNA cloning, mRNA expression, and nuclear localization. American Peptide Society 2001, 797-798 (2002).

2001

Shimohigashi, Y., Chuman, Y., Matsushima, A., Onoue, H., Ito, Y., Tomioka, K., Shimohigashi, M., and Tominaga Y.: Molecular cloning and gene expression of a circadian neuropeptide, PDF, in the cricket Gryllus bimaculatus. Comp. Biochem. Physiol., 127, 374 (2001).

Fujita, T., Inoue, N., Matsuhima, A., Nose, T., Costa, T., and Shimohigashi, Y.: Activity Enhancement by Introduction of two different halogen atoms into Phe-2-phenyl group of thrombin receptor tetherd-ligand analogs. Peptide Science 2000, 135-138 (2001).

Chuman, A., Matsushima, Nose, T., Y., Shimohigashi, and M., Shimohigashi, Y.: cDNA Cloning of circadian rhythm pacemaker neuropeptide PDF in Gryllus bimaculatus and its neuclear localization. Peptide Science 2000, 59-62 (2001).

Matsushima, A., Chuman, Y., Onoue, H., Ito, Y., Tomioka, K., Tominaga, Y., Shimohigashi, Y., and Shimohigashi M.: Gene expression of a circadian pacemaker hormone peptide PDF in cricket Gryllus bimaculatus. Peptide Science 2000, 63-66 (2001).

Sato, S., Chuman, Y., Matsushima, A., Shimohigashi, Y., Tominaga, Y., and Shimohigashi, M.: PERIOD clock protein of the summer cicada Meimuna opalifera: cDNA cloning and structural analysis. Biochem. Physiol., 130, 874 (2001).

Matsushima, A., Cuman, Y., Sato, S., Shimohigashi, Y., Tominaga, Y., and Shimohigashi, M.: cDNA cloning of a circadian rhythm pacemaker hormone PDF of the house fly Musca domestica. Comp. Biochem. Physiol., 130, 876 (2001).

2000

Matsushima, A., Fujita, , Okada, K., Yamauchi, Y., Nose, T., and Shimohigashi, Y.: Chemical syntheses of phenylalanine derivatives containing halogenated benzene ring as structural explorers for elucidation of molecular mechanisms of receptor interactions. Peptide Science 1999, 141-142 (2000).

Fujita, , Nose, T., Matsushima, A., Costa, T., and Shimohigashi, Y.: Highly potent peptide ligands for thrombin receptor. Peptide Science 1999, 421-424 (2000).

1999

Fujita,T., Nose, , Matsushima, A., Costa, T., and Shimohigashi, Y.: Importance of ligand Phe-phenyl group for activation of thrombin receptor. Peptide Science 1998, 33-36 (1999).

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